Host Protein General Information

  Protein Name
Pyruvate kinase PKM
  Gene Name
PKM
  Host Species
Homo sapiens
  Uniprot Entry Name
KPYM_HUMAN
  Protein Families
Pyruvate kinase family
  EC Number
2.7.1.40; 2.7.10.2; 2.7.11.1
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
5315
Uniprot ID
P14618
Ensembl ID
ENSG00000067225
HGNC ID
9021
  Related KEGG Pathway
Human papillomavirus infection hsa05165            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Central carbon metabolism in cancer hsa05230            Pathway Map 
Glycolysis / Gluconeogenesis hsa00010            Pathway Map 
Pyruvate metabolism hsa00620            Pathway Map 
Type II diabetes mellitus hsa04930            Pathway Map 
Glucagon signaling pathway hsa04922            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Carbon metabolism hsa01200            Pathway Map 
Biosynthesis of amino acids hsa01230            Pathway Map 
  3D Structure
PDB ID: 1T5A 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 5'UTR - 3'UTR RNA Info UV cross-linking (UVX) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver 30 h . .
Sindbis virus 5'UTR - 3'UTR RNA Info comparative RIC HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 18 h MIST = 0.160484703 .
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -23.38557859 FZR = 7.9933E-118
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -12.02005883 FZR = 3.72E-30
Ebola virus (strain VeroVP30) 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver . MIST = 0.685515177 .
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info UV cross-linking followed by antisense-mediated affinity purification and mass spectrometry HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver 30 h . .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/IPBCAMS-YL01/2020) 3'UTR RNA Info ChIRP-MS Huh7.5.1 cells . Liver 30 h MIST = 0.68551316 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 6.31445769519153e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 0.2 h P-value = 6.90597722271965e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 1 h, +IFN P-value = 6.83620611472974e-06 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 3 h, +IFN P-value = 3.97795016995344e-06 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 0.2 h, +IFN P-value = 3.8927133605526e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 3 h P-value = 3.55442902910367e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 1 h P-value = 2.78021530608493e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h P = 6.90597722271965e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h P = 3.55442902910367e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 2.78021530608493e-05 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
AMLEXANOX . 2161  D0G5UB  DGIdb
CHEMBL125044 . 379338  D0F3VE  DGIdb
CHEMBL261693 . 2767330  D01YPD  DGIdb
CHEMBL297784 . 5163  D03YPJ  DGIdb
CHEMBL35482 . 4713  D9ILC1  DGIdb
CIS-RESVERATROL . 445154  D0U3EP  DGIdb
HYDRALAZINE . 3637  D0K1XK  DGIdb
INDIRUBIN-3-MONOXIME . 3707  D0Y0ES  DGIdb
NICLOSAMIDE . 4477  D0J9ZR  DGIdb
NITAZOXANIDE . 41684  D08EBN  DGIdb
PSEUDOEPHEDRINE . 7028  D00HHS  DGIdb
SANGUINARIUM . 5154  D0T3NB  DGIdb
SULFADIAZINE, SILVER . 441244  D08JCA  DGIdb
THIRAM . 5455  D02UVS  DGIdb
TRANILAST . 5282230  D0E6OC  DGIdb
TT-232 . 6918265  D09EFC  DGIdb

Protein Sequence Information

MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
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